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Practical Considerations for T Cell Receptor (TCR) Therapies Targeting Solid Tumors
Date: Tuesday, July 17, 2018
Time: 8AM PDT | 11AM EDT | 4PM BST | 5PM CEST
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About this content
About this webcast
T Cell Receptor (TCR)-transduced T cell therapies show great promise for targeting multiple solid tumor types, including gliomas. In this webcast the speakers we will provide an overview and discuss advantage of adoptive cells therapies targeting solid tumors via expression of tumor antigen specific TCRs. They will also cover a method for rapid cloning of functional TCRs targeting glioma specific mutant peptides using a digital cell biology platform, and demonstrate the advantages of automated cell cloning, culture and functional screening via a novel high throughput cell-cell interaction assay, resulting in the rapid validation of mutant antigen specific TCRs in a matter of weeks rather than months.

During this webcast you will learn/our speaker(s) will address:

  • An introduction to TCR-transduced T cell adoptive immunotherapy targeting solid tumors.
  • Contrast the targeting of solid malignancies with chimeric antigen receptor (CAR) versus TCR engineered T cells.
  • Provide a description of current methods used for rapid identification and validation of functional TCRs.
  • Elaborate future directions and current technological bottle necks for the generation of patient-specific neoantigen TCRs.
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Speakers
Hideho Okada, MD, PhD  Hideho Okada, MD, PhD
Director, Brain Tumor Immunotherapy Center
in Neurological Surgery at University of California San Francisco
Parker Institute for Cancer Immunotherapy
Dr. Christopher A. Klebanoff  Dr. Christopher A. Klebanoff
Assistant Member
Memorial Sloan Kettering Cancer Center
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