Parkinson’s disease is one of the most well-known neurodegenerative disorders among the 600+ disorders afflicting the nervous system. This page details the known associated proteins that contribute to the disease. Parkinson’s disease (PD) is the second most common neurodegenerative disorder… Читать далее
NLPR3 Inflammasome in COVID-19
One of the potential key factors driving the cytokine storm is the interaction between the NLRP3 inflammasome and HMGB1. The viral protein E, ORF3a, and ORF8b are thought to activate the NLRP3 activation, leading to pyroptosis and release of HMGB1.… Читать далее
Best of SARS-CoV-2 Resources
Since the initial identification of SARS-CoV-2 as causative agent of COVID-19 more than 33.900.000 cases (as of 1st October 2020) have been registered worldwide. Although huge efforts are made to combat the outbreak, still no drugs or vaccines are available.… Читать далее
COVID-19 Inflammasome Dysregulation
One of the potential key factors driving the cytokine storm is the interaction between the NLRP3 inflammasome and HMGB1. The viral protein E, ORF3a, and ORF8b are thought to activate the NLRP3 activation, leading to pyroptosis and release of HMGB1.… Читать далее
Measure ATP Production in Real Time
Did you know that your cells are constantly adjusting ATP production to meet energy demands for cellular activities? Without insight into the rate of ATP production, or which pathway is contributing to ATP production, you may be missing… Читать далее