TABLE OF CONTENTS
October 2020 Volume 23, Issue 10
Communications Biology Call for Papers
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OBITUARY
Horace Barlow. Scientist of vision pp1177 — 1178
Colin Blakemore
doi:10.1038/s41593-020-00708-1
NEWS & VIEWS
Schwann cell energy to die for pp1179 — 1181
Amelia Trimarco & Carla Taveggia
doi:10.1038/s41593-020-00707-2
Starring role for astrocytes in memory pp1181 — 1182
Paul W. Frankland & Sheena A. Josselyn
doi:10.1038/s41593-020-0678-7
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REVIEW ARTICLES
Synergy between amyloid-β and tau in Alzheimer’s disease pp1183 — 1193
Marc Aurel Busche & Bradley T. Hyman
doi:10.1038/s41593-020-0687-6
Busche and Hyman review emerging evidence for an interaction between Aβ and tau during Alzheimer’s disease (AD) progression that challenges the classical linear trajectory model and offers a new perspective on AD pathophysiology and therapy.
BRIEF COMMUNICATIONS
Goal-directed actions transiently depend on dorsal hippocampus pp1194 — 1197
Laura A. Bradfield, Beatrice K. Leung, Susan Boldt, Sophia Liang & Bernard W. Balleine
doi:10.1038/s41593-020-0693-8
This study shows that the dorsal hippocampus is necessary for goal-directed action, but only transiently, during initial learning. Convergently, goal-directed actions also depend transiently on the physical context.
Prediction errors bidirectionally bias time perception pp1198 — 1202
Ido Toren, Kristoffer C. Aberg & Rony Paz
doi:10.1038/s41593-020-0698-3
Toren et al. show that outcomes that are better or worse than expected lengthen or shorten the perceived duration of stimuli, respectively, and that this interaction between teaching signals and time perception occurs in the human striatum.
ARTICLES
Epigenomic analysis of Parkinson’s disease neurons identifies Tet2 loss as neuroprotective pp1203 — 1214
Lee L. Marshall, Bryan A. Killinger, Elizabeth Ensink, Peipei Li, Katie X. Li et al.
doi:10.1038/s41593-020-0690-y
Parkinson’s disease brain neurons exhibit a widespread epigenetic dysregulation of enhancers that is linked to an upregulation of TET2. Inactivation of TET2 protects against nigral dopaminergic neuronal loss and neuroinflammation.
A glycolytic shift in Schwann cells supports injured axons pp1215 — 1228
Elisabetta Babetto, Keit Men Wong & Bogdan Beirowski
doi:10.1038/s41593-020-0689-4
Babetto et al. demonstrate an axonal injury-induced glycolytic surge in Schwann cells that supplies perturbed axons with glycolytic energy substrates. Disruption of this metabolic coupling of axons and glial cells promotes axonal degeneration.
Astrocytes contribute to remote memory formation by modulating hippocampal–cortical communication during learning pp1229 — 1239
Adi Kol, Adar Adamsky, Maya Groysman, Tirzah Kreisel, Michael London et al.
doi:10.1038/s41593-020-0679-6
Kol et al. show that the foundation of remote memory is formed during acquisition by the massive recruitment of ACC-projecting CA1 neurons. Remote memory acquisition involves projection-specific effects of astrocytes on CA1-to-ACC neuronal communication.
A prefrontal–paraventricular thalamus circuit requires juvenile social experience to regulate adult sociability in mice pp1240 — 1252
Kazuhiko Yamamuro, Lucy K. Bicks, Michael B. Leventhal, Daisuke Kato, Susanna Im et al.
doi:10.1038/s41593-020-0695-6
Yamamuro et al. show that juvenile social isolation disrupts prefrontal neurons projecting to the paraventricular thalamus and associated prefrontal somatostatin interneurons, and thereby impairs sociability in adulthood.
High-fat food biases hypothalamic and mesolimbic expression of consummatory drives pp1253 — 1266
Christopher M. Mazzone, Jing Liang-Guallpa, Chia Li, Nora S. Wolcott, Montana H. Boone et al.
doi:10.1038/s41593-020-0684-9
Mazzone and Liang-Guallpa et al. demonstrate that consuming high-fat foods rapidly and durably tunes parallel brain circuits to drive intake of a high-fat diet while devaluing a nutritionally balanced, standard diet even under states of intense hunger.
A quantitative reward prediction error signal in the ventral pallidum pp1267 — 1276
David J. Ottenheimer, Bilal A. Bari, Elissa Sutlief, Kurt M. Fraser, Tabitha H. Kim et al.
doi:10.1038/s41593-020-0688-5
The nervous system is hypothesized to calculate reward prediction errors to estimate reward availability in the environment. The authors quantify a robust prediction error signal in the ventral pallidum derived from recently received rewarding outcomes.
Active dendritic currents gate descending cortical outputs in perception pp1277 — 1285
Naoya Takahashi, Christian Ebner, Johanna Sigl-Glöckner, Sara Moberg, Svenja Nierwetberg et al.
doi:10.1038/s41593-020-0677-8
The authors showed that the ‘moment of perception’ is causally related to dendritic activity in subcortically projecting layer 5 pyramidal neurons that project to the higher-order thalamus, superior colliculus and striatum.
Systematic errors in connectivity inferred from activity in strongly recurrent networks pp1286 — 1296
Abhranil Das & Ila R. Fiete
doi:10.1038/s41593-020-0699-2
The authors demonstrate that strongly recurrent circuits inferred from neural activity, even with unlimited data from every neuron, are biased. Synapses are inferred between unconnected but correlated neurons. Inference based on non-equilibrium activity may help remedy this.
RESOURCES
Live-imaging of astrocyte morphogenesis and function in zebrafish neural circuits pp1297 — 1306
Jiakun Chen, Kira E. Poskanzer, Marc R. Freeman & Kelly R. Monk
doi:10.1038/s41593-020-0703-x
Chen et al. define previously unreported zebrafish astrocytes, provide new insights into vertebrate astrocyte development and lay the foundation for studying astrocyte function in the entire nervous system of an intact and behaving animal.
AMENDMENTS & CORRECTIONS
Author Correction: AHR is a Zika virus host factor and a candidate target for antiviral therapy p1307
Federico Giovannoni, Irene Bosch, Carolina Manganeli Polonio, María F. Torti, Michael A. Wheeler et al.
doi:10.1038/s41593-020-0700-0
Author Correction: Striatal neurons directly converted from Huntington’s disease patient fibroblasts recapitulate age-associated disease phenotypes p1307
Matheus B. Victor, Michelle Richner, Hannah E. Olsen, Seong Won Lee, Alejandro M. Monteys et al.
doi:10.1038/s41593-020-00714-3
Author Correction: Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain p1308
Julia Marschallinger, Tal Iram, Macy Zardeneta, Song E. Lee, Benoit Lehallier et al.
doi:10.1038/s41593-020-0682-y
Publisher Correction: Three-dimensional genome restructuring across timescales of activity-induced neuronal gene expression p1309
Jonathan A. Beagan, Elissa D. Pastuzyn, Lindsey R. Fernandez, Michael H. Guo, Kelly Feng et al.
doi:10.1038/s41593-020-0683-x
Publisher Correction: Distinct synchronization, cortical coupling and behavioral function of two basal forebrain cholinergic neuron types p1310
Tamás Laszlovszky, Dániel Schlingloff, Panna Hegedüs, Tamás F. Freund, Attila Gulyás et al.
doi:10.1038/s41593-020-0702-y