HMGB1 and NLRP3 dysregulation in COVID-19

One of the potential key factors driving the cytokine storm is the interaction between the NLRP3 inflammasome and HMGB1. The viral protein E, ORF3a, and ORF8b are thought to activate the NLRP3 activation, leading to pyroptosis and release of HMGB1. In high serum concentration, this damage-associated molecular pattern (DAMP) leads to excessive inflammation and further activation of the NLRP3 inflammasome. Cytokine Release Syndrome

Antibodies-online offers a range of HMGB1 & NLRP3 antibodies, proteins, and ELISA Kits to enable further studies of its role in perpetuating COVID-19:

Product Order now
anti-NLRP3 antibody (AA 1-93) ABIN1169100
anti-HMGB1 antibody (High Mobility Group Box 1) ABIN1169270
anti-IL1B antibody (Interleukin 1, beta) ABIN969215
anti-Gasdermin D (GSDMD) antibody ABIN2142907
IL1B ELISA Kit (Interleukin 1, beta) ABIN6574167
HMGB1 ELISA Kit (High Mobility Group Box 1) ABIN6574155
anti-IL 18 antibody (Interleukin 18) (AA 1-157) ABIN964783
Lipopolysaccharides (LPS) ELISA Kit ABIN6574100


Check out all Inflammasomes

Добавить комментарий

Ваш адрес email не будет опубликован. Обязательные поля помечены *