HMGB1 and NLRP3 dysregulation in COVID-19

One of the potential key factors driving the cytokine storm is the interaction between the NLRP3 inflammasome and HMGB1. The viral protein E, ORF3a, and ORF8b are thought to activate the NLRP3 activation, leading to pyroptosis and release of HMGB1. In high serum concentration, this damage-associated molecular pattern (DAMP) leads to excessive inflammation and further activation of the NLRP3 inflammasome.

Cytokine Storm

antibodies-online offers a range of HMGB1 & NLRP3 antibodies, proteins, and ELISA Kits to enable further studies of its role in perpetuating COVID-19:

ProductOrder now
Human HMGB1 ELISA KitABIN6574155
Recombinant HMGB1 antibodyABIN1169270
HMGB1 Protein (Active)ABIN1176827
Mouse HMGB1 ELISA KitABIN6574156
Rat HMGB1 ELISA KitABIN13023254
Polyclonal NLRP3 antibodyABIN184887
Monoclonal NLRP3 antibodyABIN1169100

Find more information on COVID-19 Resource Page

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