One of the potential key factors driving the cytokine storm is the interaction between the NLRP3 inflammasome and HMGB1. The viral protein E, ORF3a, and ORF8b are thought to activate the NLRP3 activation, leading to pyroptosis and release of HMGB1. In high serum concentration, this damage-associated molecular pattern (DAMP) leads to excessive inflammation and further activation of the NLRP3 inflammasome.
antibodies-online offers a range of HMGB1 & NLRP3 antibodies, proteins, and ELISA Kits to enable further studies of its role in perpetuating COVID-19:
Product | Order now |
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Human HMGB1 ELISA Kit | ABIN6574155 |
Recombinant HMGB1 antibody | ABIN1169270 |
HMGB1 Protein (Active) | ABIN1176827 |
Mouse HMGB1 ELISA Kit | ABIN6574156 |
Rat HMGB1 ELISA Kit | ABIN13023254 |
Polyclonal NLRP3 antibody | ABIN184887 |
Monoclonal NLRP3 antibody | ABIN1169100 |
Find more information on COVID-19 Resource Page