Stemcell
Next Generation Disease Modeling

Cerebral organoids have revolutionized our ability to study human neurological development and disease. Pairing these physiologically relevant cerebral organoid models with new advancements in genome editing technology has further enabled researchers to answer questions in ways they never thought possible. Watch our virtual poster presentation to see how our scientists generated gene-edited cerebral organoids to model microcephaly.

CRISPR-Cas9 Gene Editing of Cerebral Organoids to Model Microcephaly

In this virtual poster presentation, Leon Chew discusses his work gene editing cerebral organoids to model microcephaly. Chew will walk you through how he used CRISPR-Cas9 to generate a mutated hPSC cell line, characterized the stable clones for cell quality attributes, and differentiated the cells to cerebral organoids.

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Additional Resources:
VIDEO

How to Grow Cerebral Organoids

Our step-by-step video guide for growing cerebral organoids from human pluripotent stem cells. We’ll walk you through embryoid body formation, induction, expansion, and organoid maturation.

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WEBINAR

Modeling Human Brain Development in a Dish

Dr. Madeline Lancaster discusses how cerebral organoids are being used in neurological disease and development research.


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NEWS

Our Favorite Science from 2018

Find out which breakthroughs and news stories captivated and inspired our scientists. The selection covers advances in organoids, immunotherapy, genome editing, and more!

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Keep up to date with organoid-related content by following the STEMCELL Organoids Twitter account, @organoidscience. For more information about cerebral organoid model systems, visit us online, or contact me directly with any questions you may have.

JASON HAMLIN, PhD
ASSOCIATE PRODUCT MANAGER, NEUROSCIENCE
RESEARCH & DEVELOPMENT

STEMCELL TECHNOLOGIES
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E.  JASON.HAMLIN@STEMCELL.COM
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