The Jackson Laboratory: Leading the search for tomorrow’s cures

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Aged B6 Mice: An Essential Tool for Preclinical Discovery in Human Disease
November 15, 1:00 p.m. ET, 6:00 p.m. GMTSeverity of and susceptibility to disease differ between the young and old. Many diseases are chronic and progressive in their development, only reaching recognizable severity in older individuals. In order to assist the biomedical community in understanding and developing treatments for age related diseases, JAX offers aged C57BL/6J male and female mice. This webinar presents phenotypic data, published applications, and informational resources to help researchers use these mice effectively and efficiently in their research programs. Join this webinar to:

  • Understand when key phenotypes change as mice age
  • Examine age related changes in metabolism
  • Discuss neurological changes in aged mice
  • Explore age related immunological deficiencies related to metabolic disease and cancer
  • Review JAX resources that support aging research

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CRISPR/Cas9: Moving from Founders to Phenotyping
November 28, 9:00 a.m. ET, 2:00 p.m. GMTCRISPR/Cas9 techniques are quickly growing in popularity for the generation of new mouse models for research. Many researchers struggle with understanding the complexities associated with the diverse alleles that can be generated, how to deal with mosaicism, and how to move from a single founder mouse to larger cohorts for phenotype characterization. In this webinar, we will discuss the following topics:

  • The molecular mechanisms that drive the array of possible mutations that can result from a single Cas9/sgRNA targeting strategy
  • Various common targeting strategies to generate indel, knockout, and knockin mutations using CRISPR/Cas9
  • Selection of founder mice and breeding strategies for mitigating mosaicism in founder mice
  • Breeding strategies to establish a colony and generate cohorts for experimentation

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*All JAX Webinar™ registrants will receive links to webinar video recordings and presentation slides.

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